Home CHEST Thought Leaders March #pulmCC Twitter Chat: The State of Sepsis: Revisions, Advancements, New Therapies

March #pulmCC Twitter Chat: The State of Sepsis: Revisions, Advancements, New Therapies

Join us Wednesday, March 21 at 7 pm Central/8 pm Eastern as we discuss another hot topic in pulmonary, critical care, and sleep medicine. The topic? Sepsis!

Sepsis is a leading cause of death in hospitalized patients, affecting more than a million Americans every year. Improving outcomes and early detection of sepsis have been pushed by the CDC and major medical organizations, including CHEST. In this #pulmcc Twitter chat, we’ll discuss some of the major issues in the identification and treatment of sepsis and will be joined by experts Dr. Steve Simpson (@sqsimp) and Dr. Alex Niven (@niven_alex). We hope you’ll join us!

We are offering CME credit for participation in this Twitter chat! For additional information on eligibility and how to claim, learn more here. NOTE: To receive CME credit, you must complete the survey in the learning site within three (3) days after the Twitter chat.

CHEST members, if you’ve joined a CHEST Twitter chat, you are eligible to receive participation points for each chat you’ve participated in. Claim them here.


T1: Why did we change the definition of sepsis? Why do we care?

T2: Is early goal-directed therapy dead? Or is there something we can learn?

T3: Are early antibiotics really important? If so, how early?

T4: Should we be using vitamin C and steroids to treat our septic shock patients?


1. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016; 315(8): 801-810. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968574/pdf/nihms794087.pdf 

2. Simpson SQ. New sepsis criteria: a change we should not make. Chest. 2016; 149(5): 1117-1118. http://journal.chestnet.org/article/S0012-3692(16)41523-0/fulltext

3. The PRISM Investigators. Early, goal-directed therapy for septic shock—a patient-level meta-analysis. N Engl J Med. 2017; 376:2223-2234. http://www.nejm.org/doi/full/10.1056/NEJMoa1701380

4. Dell'Anna AM, Taccone FS. Early-goal directed therapy for septic shock: is it the end? Minerva Anestesiol. 2015;81(10):1138-1143. https://www.ncbi.nlm.nih.gov/pubmed/26091011

5. Marik PE, Khangoora V, Rivera R, et al. hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock. CHEST 2017; 151(6): 1229-1238. http://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext